Christopher Columbus. The great navigator suffered from gout or rheumatoid polyarthritis
The diaries written and left by Christopher Columbus they are for us a precious source of historical information in general about his time, but also about the navigator himself ( see https://www.pilloledistoria.it/6439/notizie/non-e-la-santa-maria-di-cristoforo-colombo).
From them we learn that Columbus suffered from a pathology, although it is still not entirely clear what it was.
The discoverer of America cites signs of "complete exhaustion" which he attributes to gout, a very common disease at the time, but scholars are more likely to believe that it was rheumatoid polyarthritis , which in turn causes endocarditis .
Hence, probably, the continuous "exhaustion" that the Genoese refers