* Native American alliances: The Yamasee War disrupted Native American alliances in the Southeast, as the Yamasee and their allies turned against their former Creek and Cherokee allies. This led to a period of instability and conflict among Native American tribes in the region.
* British-Spanish relations: The Yamasee War also strained British-Spanish relations, as the British accused the Spanish of aiding and abetting the Yamasee. This led to increased tensions between the two powers, which eventually culminated in the War of Jenkins' Ear in 1739.
* South Carolina's defenses: The Yamasee War exposed the weaknesses of South Carolina's defenses, and the colony was forced to rely on British military assistance to repel the attacks. This led to increased British influence in South Carolina, which eventually became a royal colony in 1729.
* African American slavery: The Yamasee War also had a significant impact on African American slavery in the Southeast. Many African slaves joined the Yamasee in their rebellion, and the war led to a decrease in the number of slaves in the region. This, in turn, led to an increase in the demand for African slaves from the Caribbean and Africa.
Overall, the Yamasee War was a major turning point in the history of the Southeast. It had a profound impact on Native American alliances, British-Spanish relations, South Carolina's defenses, and African American slavery. The war also marked the beginning of a new era of British imperialism in the region, as the British government became more involved in the affairs of the Southeast.