- 1519: Magellan sets out from Spain with five ships to find a western route to the Spice Islands.
- 1520: Magellan reaches the Strait of Magellan, which he names after himself.
- 1521: Magellan enters the Pacific Ocean, becoming the first European to do so.
- 1521: Magellan is killed in a battle with the natives of the Philippine Islands.
- 1522: The remaining ships of Magellan's expedition complete the circumnavigation of the world, returning to Spain.