* Lack of funding: LaSalle's expeditions were often underfunded, which made it difficult for him to recruit and equip a crew, as well as purchase the necessary supplies. This problem was compounded by the fact that LaSalle was often in debt.
* Hostility from Native American tribes: The French explorer often faced hostility from Native American tribes, who were wary of the French presence in the New World. This hostility sometimes led to violence, which further depleted LaSalle's supplies and manpower.
* Disease: Disease was a major problem for LaSalle and his crew. Many of his men died from diseases such as malaria, yellow fever, and dysentery.
* Uncooperative crew: LaSalle's crew was often uncooperative and mutinous. This was due in part to the harsh conditions of the expeditions, but also to LaSalle's own personality. LaSalle was a demanding leader who often drove his men to the point of exhaustion.
* Bad weather: LaSalle's expeditions were often plagued by bad weather, which made it difficult to travel and hunt for food.