Native Americans at Nuestra Senora de la Soledad were forced into a harsh life of servitude and exploitation. They were forced to work in the fields, often under harsh conditions, and were often whipped or beaten for minor infractions. They were also subjected to sexual abuse and cultural and religious oppression, as the Spanish tried to convert them to Catholicism and suppress their traditional beliefs and practices. Many Native Americans died due to overwork, malnutrition, disease, and abuse, leading to a significant decline in their population over time.