- Leonardo da Vinci (1452-1519): Leonardo da Vinci was a polymath who is considered to be one of the greatest painters of all time. He also made important contributions to the fields of science, mathematics, engineering, and anatomy.
- Michelangelo (1475-1564): Michelangelo was a sculptor, painter, architect, and poet who is considered to be one of the greatest artists of the Italian Renaissance. His most famous works include the Pietà, the David, and the Sistine Chapel ceiling.
- Christopher Columbus (1451-1506): Christopher Columbus was an Italian explorer who is credited with discovering the Americas in 1492.
- Galileo Galilei (1564-1642): Galileo Galilei was a mathematician, astronomer, and physicist who made important contributions to the scientific revolution. He was the first person to use a telescope to observe the stars and planets, and he discovered that the Earth revolves around the Sun.