The conquistadors brought with them advanced weaponry, such as guns and cannons, which were far more powerful than the weapons used by the indigenous peoples of the Americas. They also had superior armor and horses, which gave them a significant advantage in combat.
In addition, the conquistadors were often able to exploit the rivalries and divisions among the indigenous peoples. They were able to form alliances with some groups against others, which allowed them to conquer large areas with relatively small numbers of troops.
The conquistadors also benefited from the fact that the indigenous peoples had no immunity to European diseases, such as smallpox and measles. These diseases decimated the native population and further weakened their resistance to the Spanish invaders.
Finally, the conquistadors were driven by a strong desire for wealth and glory. They believed that they could find riches in the New World and make a name for themselves by conquering new lands. This ambition led them to take great risks and endure great hardships in their pursuit of success.